活动主题：Quadruplexes are everywhere！

主讲人：Jean-Louis Mergny教授，巴黎综合理工学院，欧洲科学院院士

活动时间：2026年1月16日（周五）下午15:00-16:00

活动地点：电化学楼C512

报告人简介：Jean-Louis Mergny教授，现任职于巴黎综合理工学院，光学和生物科学实验室主任。2019年入选欧洲科学院院士和法国生物化学和分子生物学学会会士，也是法国国家健康与医学研究院院士。Mergny教授主要从事特殊DNA结构的生物物理化学性质及在纳米技术中的应用研究。曾获法兰西科学院“Labbey”奖（2000），法国生物化学与分子生物学会“Maurice Nicloux” 奖（2001），法国国家健康与医学研究院“Therapeutical research”奖（2002）。在Science, Nature Medicine, Nature Chem. Biol. 等期刊发表论文200多篇，他引超过40000次，h-index 96。

   内容摘要：Beyond the iconic double-helix, DNA and RNA are prone to structural polymorphism. I have dedicated my whole career to these “weird” nucleic acid structures. For example, we are developping tools to study the folding and polymorphism of unusual nucleic acid structures and to understand how they can compete with regular duplex-formation. G-quadruplexes (G4s), which are often found in aptamer sequences, are involved in key biological processes, including transcription, and can contribute to tumorogenesis. We designed and applied an algorithm for the prediction of G4 propensity to a variety of genomes, including cancer genomes, and then used a variety of biochemical and in cell techniques to confirm these predictions in a variety of organisms.